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Pharmacological action Tylenol #3 with Codeine:
Tylenol #3 with Codeine combined drug action is due to the effects of its constituent components. Acetaminophen has analgesic and antipyretic action. Codeine has a central antitussive effect (due to the suppression of the excitability of the cough center), and the analgesic effect due to stimulation of opiate receptors in different regions of CNS and peripheral tissues, leading to stimulation of the antinociceptive system and change the emotional perception of pain. To a lesser extent than morphine, respiratory depression, less likely to cause cramps, nausea, vomiting, and constipation (activation of opioid receptors in the gut causes relaxation of smooth muscle, decreased motility and spasm of the sphincter of all). The duration of analgesic action – 4 hours, antitussive – 4-6 pm
Indications Tylenol #3 with Codeine:
Pain syndrome of mild to moderate severity (migraine, headache, toothache, neuralgia, radicular syndrome, arthralgia, musculoskeletal injuries unit). Colds, the flu (as an antipyretic and antitussive drugs).
Contraindications Tylenol #3 with Codeine:
Hypersensitivity, severe renal / hepatic failure, hematopoiesis, genetically caused deficiency of glucose-6-phosphate dehydrogenase, respiratory failure due to inhibition of the respiratory center, pulmonary insufficiency, pregnancy, lactation, children’s age (12 years).
Side effects Tylenol #3 with Codeine:
Nausea, vomiting, and epigastric pain. Allergic reactions (skin rash, itching, angioedema), very rarely – anemia, thrombocytopenia, methemoglobinemia and liver and kidney. With prolonged use at high doses – the development of drug zavisimosti.Peredozirovka. Symptoms: agitation, nausea, tightness in the head, insomnia, hypoglycemia, hemolytic anemia, cyanosis, bronchospasm. Can accelerate the development of severe respiratory failure. In the application of acetaminophen in high doses (greater than 10 g / day) or long-term treatment of 3-4 g / day of necrosis of the liver and kidney damage. In high doses, acetaminophen is metabolized to N-acetyl-p-benzoquinone, which is the cause of liver disease. Treatment: gastric lavage, activated charcoal.
Dosage and administration Tylenol #3 with Codeine:
Inside, 1-2 tablets every 4 hours but not more than 8 tablets per day. As an antipyretic drug is not recommended to take without consulting a doctor for more than 3 days, and as an analgesic – more than 5 days.
Special instructions Tylenol #3 with Codeine:
Avoid joint reception with other drugs containing acetaminophen, as well as expectorant drugs. Do not exceed recommended dose. During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require your full attention and psychomotor speed reactions.
Interaction Tylenol #3 with Codeine:
Enhances the effect of antiplatelet agents that may cause adverse reactions. Codeine increases the effect of ethanol on psychomotor performance. Inducers of microsomal oxidation (barbiturates, protivoepileticheskie drugs, rifampicin and ethanol) increased the risk of hepatotoxicity. Simultaneous treatment with MAO inhibitors causing ataxia, hypotension, paraesthesias, disturbance of accommodation. Drugs that suppress the central nervous system, increase the sedative effect and inhibitory effect on the respiratory center. Oral contraceptives drugs is 20-30% lower rate of metabolism of Acetaminophen.
